CAS号134-32-7

CHEMICAL IDENTIFICATION RTECS NUMBER :QM1400000 CHEMICAL NAME :1-Naphthylamine CAS REGISTRY NUMBER :134-32-7 BEILSTEIN REFERENCE NO. :0386133 LAST UPDATED :199710 DATA ITEMS CITED :58 MOLECULAR FORMULA :C10-H9-N MOLECULAR WEIGHT :143.20 WISWESSER LINE NOTATION :L66J BZHEALTH HAZARD DATAACUTE TOXICITY DATA TYPE OF TEST :LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE :Intraperitoneal SPECIES OBSERVED :Rodent - mouse DOSE/DURATION :96 mg/kg TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value TYPE OF TEST :LDLo - Lowest published lethal dose ROUTE OF EXPOSURE :Subcutaneous SPECIES OBSERVED :Rodent - rabbit DOSE/DURATION :300 mg/kg TOXIC EFFECTS :Behavioral - tremor

Behavioral - muscle weakness TYPE OF TEST :LDLo - Lowest published lethal dose ROUTE OF EXPOSURE :Oral SPECIES OBSERVED :Mammal - species unspecified DOSE/DURATION :4 gm/kg TOXIC EFFECTS :Details of toxic effects not reported other than lethal dose value TYPE OF TEST :TDLo - Lowest published toxic dose ROUTE OF EXPOSURE :Intraperitoneal SPECIES OBSERVED :Rodent - rat DOSE/DURATION :1300 mg/kg/13W-I TOXIC EFFECTS :Tumorigenic - equivocal tumorigenic agent by RTECS criteria

Blood - leukemia TYPE OF TEST :Morphological transformation TYPE OF TEST :DNA damage TYPE OF TEST :DNA damage TYPE OF TEST :DNA inhibition TYPE OF TEST :Sister chromatid exchange TYPE OF TEST :Sperm MorphologyMUTATION DATA TEST SYSTEM :Mammal - dog REFERENCE :EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing

Office, Supt of Documents, Washington, DC 20402) No.1- 1972-

Volume(issue)/page/year: 49,125,1983

*** REVIEWS ***

IARC Cancer Review:Animal Inadequate Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)

V.1- 1972- Volume(issue)/page/year: 4,87,1974

IARC Cancer Review:Human Inadequate Evidence

IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals

to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)

V.1- 1972- Volume(issue)/page/year: 4,87,1974

IARC Cancer Review:Group 3

IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49

Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:

7,260,1987

TOXICOLOGY REVIEW

KHZHAZ Khimiya i Zhizn. Chemistry and Life. (V/O Mezhdunarodnaya Kniga,

113095 Moscow, USSR) V.1- 1965- Volume(issue)/page/year: 12(2),85,1976

TOXICOLOGY REVIEW

ADCSAJ Advances in Chemistry Series. (American Chemical Soc., Distribution

Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) No.1-

1950- Volume(issue)/page/year: 13,271,1970

*** U.S. STANDARDS AND REGULATIONS ***

MSHA STANDARD:skin-HUMAN CARCINOGEN, NO ASSIGNED TWA

DTLWS* "Documentation of the Threshold Limit Values for Substances in

Workroom Air," Supplements. For publisher information, see 85INA8.

Volume(issue)/page/year: 3,24,1973

OSHA PEL (Construc):see CFR 29,1926.1104

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

29,1926.55,1994

OSHA-cancer suspect agent

CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.

of Documents, Washington, DC 20402) Volume(issue)/page/year:

29,1910.1004,1987

*** OCCUPATIONAL EXPOSURE LIMITS ***

OEL-SWEDEN;Carcinogen JAN 1993

*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :

NIOSH REL TO alpha-NAPHTHYLAMINE-air:CA use 29 CFR 1910.1004

REFERENCE :

NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of

Health, Education, and Welfare, Reports and Memoranda.

Volume(issue)/page/year: DHHS #92-100,1992

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :

NOHS - National Occupational Hazard Survey (1974)

NOHS Hazard Code - 84304

No. of Facilities: 66 (estimated)

No. of Industries: 2

No. of Occupations: 2

No. of Employees: 610 (estimated)

NOES - National Occupational Exposure Survey (1983)

NOES Hazard Code - 84304

No. of Facilities: 268 (estimated)

No. of Industries: 1

No. of Occupations: 5

No. of Employees: 2132 (estimated)

No. of Female Employees: 1796 (estimated)

毒理学数据：

1.急性毒性[12] LD50：680mg/kg（大鼠经口）；96mg/kg（小鼠腹腔）

2.刺激性 暂无资料

3.致突变性[13] 微生物致突变：鼠伤寒沙门菌10μg/皿。DNA修复：大肠杆菌25mg/L。DNA损伤：大鼠腹腔内2790μmol/kg。程序外DNA合成：大鼠肝700μmol/L。细胞遗传学分析：仓鼠成纤维细胞60mg/L（48h）

4.致癌性[14] IARC致癌性评论：组3，现有的证据不能对人类致癌性进行分类。

生态数据：

1.生态毒性[15] LC50：25mg/L（48h）（青鳉）

2.生物降解性[16]

好氧生物降解（h）：672~4320

厌氧生物降解（h）：2688~17280

3.非生物降解性[17]

水中光氧化半衰期（h）：62.4~3480

空气中光氧化半衰期（h）：0.292~2.92